When comparing Molokai vs Base16 family, the Slant community recommends Molokai for most people. In the question“What are the best VIM color-schemes?” Molokai is ranked 2nd while Base16 family is ranked 9th.
Ranked in these QuestionsQuestion Ranking
Pro Looks great
Pro One of the most common dark themes
Default for Sublime Text, avaialble on IntelliJ products and Eclipse via plug-in. Usually ranked in top 3 of highest downloaded theme for a IDE.
Pro Strong enough contrast
Without being fully black on white (which is good on modern already very contrasted screens) it remains pretty dark compared to many alternatives; making it more readable.
Pro Easy to install with Vundle
Pro Contains many color-schemes
Pro Out of the box support for many applications (vim, terminals, etc...)
Base16 template repositories on github have configurations for most popular applications where a color scheme can be applied. This reduces headache for users when applying or switching color schemes.
Pro Its Solarized Dark scheme is compatible with htop
This is just one example of an app that doesn't work with vanilla Solarized Dark (half of the usernames in htop have the same color as the background)
One has to use a patched htop version.
Con That pink
The pink color is too vibrant if compared with others. It pops out from context and may blend with red errors in some editors.
Con Too much contrast
Con Schemes are limited to 16 colors
You may not be able to use as many colors as you want for a particular application without manual manipulation since base 16 color schemes are limited to 16 colors.
Con Each theme needs manual tweaking
The base16 color schemes are really great but as a vim theme they require a lot of manual tweaking to be viable. One example is that in one theme a neon green bg is used with a white fd rendering any part of the vim UI that uses those two colors together illegible.