When comparing Scratch vs PICO-8, the Slant community recommends PICO-8 for most people. In the question“What are the best game engines for point & click adventure games?” PICO-8 is ranked 38th while Scratch is ranked 45th. The most important reason people chose PICO-8 is:
Because it's an all in one product, you don't have to worry about things like how to load sprites.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Visual
Code is represented as visual building blocks that makes it easy to understand how a program is put together.
Pro Great starting point for kids
Scratch was developed specifically for kids ages 8 and up as an exciting way to introduce them to technology. It's designed to be easy to learn, but still provides good depth in computational thinking.

Pro Easy to learn
Scratch is designed to teach computational thinking rather than focus on specific syntax. It was designed specifically to be easy to learn for anyone over the age of 8.
Pro Highly structured
The language is highly structured. Therefore, it gives you the essentials of how to think like a programmer and teaches you good programming practices from early on, so you could write clean, working and readable code in the future.

Pro No need to be able to type

Pro Can be used to create games

Pro Takes away the pain of having to wire things together
Because it's an all in one product, you don't have to worry about things like how to load sprites.

Pro Very simple programing language
It's lua with a few modifications.

Pro Encourages building simple games
As a beginner it's all to tempting to try to make the games you like to play, like Zelda or Call of Duty when we should probably be making pong.
Pro Restrictions of tokens count "forces" to write code effectively
When you reach 8192 tokens, you're screwed. However, this limit can teach you to take a look at entire code and think how you could optimize it.
Pro Possible writing code in external editor
Since launch of 0.1.12c version of software, you can now write and include external script using the same directive just like in C / C++.

Pro Perhaps one of the easiest sound editors around

Pro Share the game in a .png file with other Pico-8 users

Pro You can read the code of any game you play

Pro Lots of examples
Almost every game made for the Pico-8 is open source (if you can download the .png, you can see the source).
Also there's the fancy Pico-8 "fanzine" that has lots of code examples as well as other great tutorials in a beautiful physical or PDF form.

Pro Easy to get things going very quickly
Cons
Con For kids
For kids.
Con Won't get you a job
Scratch is not a language used in the workplace. Instead it teaches computational thinking, helping to create a foundation to aid in learning other languages.
Con Does not teach you programming
Learning Scratch might help you if you have high difficulty with logical thinking. However, starting with a proper programming language, especially an easy one, will give you the benefits of starting with something like Scratch and everything else.
Con Strange OOP
Scratch has a very strange implementation of OOP that is sprite based, and will become very confusing when you move to other languages.
Con Weird
It's straight up weird.

Con No collision library or other common things
Pico-8 is very minimalistic and as such doesn't come with really any abstractions whatsoever which means often you end up re-inventing the wheel.

Con Code editor leaves some things to be desired
Such as code completion and automatic indentation.

Con Costs 15$
Unlike many of the other frameworks it's not free. However this is kind of a feature because it means it's much more likely to be supported.

Con Memory restrictions could be confusing or frustrating to a beginner
