When comparing Visual Studio with the Python Tools extension vs Spyder, the Slant community recommends Spyder for most people. In the question“What are the best Python IDEs or editors?” Spyder is ranked 3rd while Visual Studio with the Python Tools extension is ranked 36th. The most important reason people chose Spyder is:
Released under the MIT license.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Autocompletion based on variable types
Has smart autocompletion based on variable types
Pro Cloud storage through VS Online
Your Visual Studio Online account gives you a place to store your code, backlog, and other project data with no servers to deploy, configure, or manage.
Pro Web based interface to track project progress
In agile development teams one really needs features such as product backlogs where you can assign features to team mates and track their progress on them. VS provides a web based interface for you to track your team's complete progress on the project.
Pro Free and open-source
Released under the MIT license.
Pro Graph plotting support
Spyder can plot graphs and provide the list of all variables.
Pro Enables to write consistent code
Pylint integration enables to check the code for PEP8 style guide and detect errors.
Pro Powerful autocompletion
Spyder's autocomplete features are made possible by a library called rope which gives Spyder powerful autocompletion.
Pro Has cross platform support - Linux, Mac, and even Windows
Spyder (formerly Pydee) has support for all of the major operating platforms - Linux, Mac, and even Windows.
Pro Helps you to use documentation
Pro Intuitive interface
Pro Relatively lightweight
Pro Has support for Vim bindings via plugin support
Aside from being an open sourced, actively developed IDE, vim key-binding support is also available. If you remember Pydee - this is it, albeit with a new name.
Pro Good GitHub project
Pro Excellent variable explorer
Dynamic variable explorer with editor and visualizer
Pro Completely Python
Cons

Con Windows only
Visual Studio is only available on Windows, though there is now a cross-platform derivation of Visual Studio named Visual Studio Code. It is has less features and is more of a code editor than an IDE.

Con Proprietary
Visual Studio is a proprietary software.
Con Not beautiful
The default theme is not beautiful. And there are not many themes.
Con The documentation is poor when it comes to debugging
Not a lot of information about debugging is available in the documentation.
Con Consumes a lot of memory
If you're working with large data, especially arrays, another IDE should be considered as spyder uses at least 200-300Mb of memory.
