When comparing Neo Textures vs Substance Designer, the Slant community recommends Neo Textures for most people. In the question“What are the best programs to create procedural textures?” Neo Textures is ranked 4th while Substance Designer is ranked 8th. The most important reason people chose Neo Textures is:
Can easily modify all of the multipliers and alligorithm values of procedural generation.
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Pros
Pro Powerful control on procedural nodes
Can easily modify all of the multipliers and alligorithm values of procedural generation.
Pro Faster than Substance Designer
Pro Open-source
Neo Textures editor is a free and open source project available on SourceForge.
Pro Native integration with many game engines
It has the ability to export sbsar files, these can be put into most game engines allowing in engine tweaking of procedural content.
Pro Ability to create custom substance files
Substance designer allows users to create custom substance files, it offers a lot of power with a mix of workflow of working with procedural textures and bitmaps.
Cons
Con No longer being developed
Neo Textures is no longer being developed. The project seems to be abandoned.
Con Doesn't support PBR
Neo Textures was created before PBR was a thing, and it's based on the deprecated Diffuse/Specular rendering pipeline, which is no longer used.
Con Lot of bugs
Con Expensive
The pricing starts at $20 for the indie license and $100 for the pro license.
Con Not good for painting textures
Substance designer is not very powerful when it comes to painting textures, while there are 2D painting tools, they are not very good.