When comparing Substance Designer vs Substance Painter, the Slant community recommends Substance Painter for most people. In the question“What are the best 3D texture painting softwares?” Substance Painter is ranked 2nd while Substance Designer is ranked 14th. The most important reason people chose Substance Painter is:
Since Substance Painter allows users to paint in full 3D, it can be used not only to paint full textures, but can also paint masks which can then be used in other tools (like Substance Designer) for material filter generators (like the ones used to make edge wear and dirt)
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Pros
Pro Native integration with many game engines
It has the ability to export sbsar files, these can be put into most game engines allowing in engine tweaking of procedural content.
Pro Ability to create custom substance files
Substance designer allows users to create custom substance files, it offers a lot of power with a mix of workflow of working with procedural textures and bitmaps.
Pro Allows you to paint in full 3D
Since Substance Painter allows users to paint in full 3D, it can be used not only to paint full textures, but can also paint masks which can then be used in other tools (like Substance Designer) for material filter generators (like the ones used to make edge wear and dirt)
Pro Painting and procedural editing of textures
Cons
Con Expensive
The pricing starts at $20 for the indie license and $100 for the pro license.
Con Not good for painting textures
Substance designer is not very powerful when it comes to painting textures, while there are 2D painting tools, they are not very good.
Con Expensive and impossible to run without an expensive graphics card
The free trial is the only thing free. You'll have to pay a lot of money for the full version, and even if you do get it, you will have to pay for an expensive graphics card to use it, which means a lot more money flying out of your wallet and/or bank account.
Con Cannot export in a procedural format
You can not export substance (sbsar) files in Painter.