When comparing Substance Designer vs Sculptris, the Slant community recommends Sculptris for most people. In the question“What are the best 3D texture painting softwares?” Sculptris is ranked 10th while Substance Designer is ranked 14th. The most important reason people chose Sculptris is:
Sculptris is provided free of charge from Pixologic.
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Pros
Pro Native integration with many game engines
It has the ability to export sbsar files, these can be put into most game engines allowing in engine tweaking of procedural content.
Pro Ability to create custom substance files
Substance designer allows users to create custom substance files, it offers a lot of power with a mix of workflow of working with procedural textures and bitmaps.
Pro Free
Sculptris is provided free of charge from Pixologic.
Pro Sculpting allows for easier creative expression
Sculptris has great editing tools that allow designers to concentrate on sculpting and completely immerse themselves into making models, forgetting about all the complex methods modelers usually have to use in their daily business.
Pro Works on Lower-End Devices
Sculptris is essentially a lesser version of ZBrush that works on low-end PCs.
Cons
Con Expensive
The pricing starts at $20 for the indie license and $100 for the pro license.
Con Not good for painting textures
Substance designer is not very powerful when it comes to painting textures, while there are 2D painting tools, they are not very good.
Con Small scope
Doesn't do much besides sculpting.
Con No Linux version
Only for Windows and Mac.