When comparing AdAway vs uBlock Origin (as a Firefox addon), the Slant community recommends AdAway for most people. In the question“What are the best ad blockers for Android?” AdAway is ranked 1st while uBlock Origin (as a Firefox addon) is ranked 4th. The most important reason people chose AdAway is:
Use the hosts files to block ads, so it works for everything.
Specs
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Pros
Pro System wide blocking
Use the hosts files to block ads, so it works for everything.
Pro Doesn't consume CPU time or memory
The app updates the hosts file periodically but doesn't need to run in the background in order to block ads, which is especially convenient for older phones.
Pro Can use systemless host
Can be used without modifying the system if rooted with magisk.
Pro Can use custom host files
Lots of people and keep their own updated host files used for blocking ads and ad away supports loading them in or even adding their source for autoloading.
Pro Fastest loading times
Pro Promised to remain commercial interest free
uBlock will remain free from any commercial as stated by the creator. uBlock is meant to be strictly for the users and completely free.
Cons
Con Needs root (by design)
Needs root to update the hosts file.
Con Won't block same domain ads
Because the host file can only redirect domains, if the ad and content are on the same domain the ad will be displayed.
Con Doesn't block background ads yet
Ads that replace the background image of a website are currently beyond the scope of the ad-blocker, but the functionality is planned to be added in the future.