When comparing Cython vs Boo, the Slant community recommends Cython for most people. In the question“What are the best languages to learn for someone coming from Python?” Cython is ranked 13th while Boo is ranked 14th. The most important reason people chose Cython is:
It's basically C with Python syntax.
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Pros
Pro Good for interfacing C/C++/Fortran libs
It's basically C with Python syntax.
Pro Used a lot in the data science community
Pro Full control over the types
Pro IDE support
The open-source #develop comes with Boo support.
Pro Static type safety
This also improves performance as compared to IronPython. You can still use duck typing if you want, but you mostly don't need to since Boo can infer the type based on context.
Pro Inter-operates with other .NET languages
Boo runs on the .NET platform, so you can pretty much use it for anything C# is good for.
Pro One of Unity's supported languages
Use your Python skills to make games.
Pro Familiar syntax
Boo's syntax was heavily influenced by Python's, but makes some improvements like macros and multi-line lambdas.
Cons
Con The documentation isn't as good as Python's
There are some Boo textbooks. You can also find examples of Boo's language features in the Git repository, but it doesn't seem to have a thorough description of the language itself like Python does.