When comparing CFML vs F#, the Slant community recommends F# for most people. In the question“What is the best programming language to learn first?” F# is ranked 30th while CFML is ranked 73rd. The most important reason people chose F# is:
F#'s syntax tends to be terse while remaining very readable and easy to understand without being a chore to write.
Specs
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Pros

Pro Rapid application development
Get a web app up and running fast with stuff built right in to CFML! Frameworks make it even faster but lengthen the learning curve.

Pro Easily query a database
Newcomers can use an html-like syntax to query a database. Advanced developers can use a scripted syntax to execute stored procedures.
Pro Multiple engine implementations available
There are multiple engine implementations available including Adobe ColdFusion, Lucee, New Atlanta BlueDragon, Railo, and Open BlueDragon among others.
Pro Quick document and image manupulation
ColdFusion can quickly interact with PDFs , Spreadsheets to read/manipulate the data. There are a lot of built in functions to manipulate images quickly.
Pro Concise syntax
F#'s syntax tends to be terse while remaining very readable and easy to understand without being a chore to write.
Pro Easier transition from other paradigms
Since F# is not a purely functional language, it lends itself to being more easily picked up by programmers that have experience with other paradigms.
Pro .NET Interoperability
Since F# runs on the Common Language Runtime or CLR, it has access to the entire .NET Framework, as well as libraries written in other .NET languages such as C#, VB.NET, and C++/CLI.
Pro Multiplatform, it runs on .Net Core
Forget Xamarin and Mono. F# now runs on the multiplatform .Net Core!
Pro You can run F# in the browser
Thanks to a project like Fable, you can write and run your client app in F# and run it over JavaScript. It allows you to share code between your server and client.
Pro Natively supported by Visual Studio
This is a .Net language natively supported by Visual Studio. Though it is not as tooled up as C# the support is still substantial. In particular, C# deployment scenarios can be enabled for it with small C# wrapper projects. Integration with Visual Studio provides: IntelliSense, debugging, projects an other features.
Pro Fall into the pit of success
F# directs you into a workflow where the right way is the path of least resistance.
Coming from a C# background, its restrictions might feel arbitrary at first (e.g., what do you mean my code has to be in dependency order!? Arbitrary alphabetical or bust!), but you'll soon realize that your code is cohesive, concise and consistent in a way that it never was before - and you can compile and run with confidence!
Pro F# is supported by Xamarin
Thanks to Xamarin, F# is a functional language that you can use to build for iOS, Android and Windows.
Cons
Con Little actual use either in academia or professionally
Con Has no ad-hoc polymorphism (á la Type Classes)
You have generics, you have interfaces, you have inheritance, you have a lot of things at your disposal but you don't have Type Clases. They can be emulated using some clever constructs but there's nothing like having the real thing.
Con Infested with OOP
Still relying on .NET OOP libraries.
