When comparing Flask vs Grails, the Slant community recommends Flask for most people. In the question“What are the best web frameworks to create a web REST API?” Flask is ranked 7th while Grails is ranked 28th. The most important reason people chose Flask is:
Flask is very easy to get up and going, with vanilla HTML or with bootstrap pieces. It doesn't take much lines of Python to load Flask to get headers working, etc, and since it's all modular you don't have to have something you don't want in your application.
Specs
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Pros
Pro Minimalist without losing power
Flask is very easy to get up and going, with vanilla HTML or with bootstrap pieces. It doesn't take much lines of Python to load Flask to get headers working, etc, and since it's all modular you don't have to have something you don't want in your application.
Pro Lots of resources available online
Flask is one of the most popular Python web frameworks, if not the most popular one. As such, there's plenty of guides, tutorials, and libraries available for it. A large number of important Python libraries, such as SQLAlchemy have libraries for Flask, which add valuable bindings to make the development process and the integration between these libraries and Flask as easy as possible.
Pro Extremely easy to build a quick prototype
Even though it's pretty minimalistic out of the box, Flask still provides the necessary tools to build a quick prototype for a web app right after a fresh install. With all the main components pretty much packed in the flask
package, building a simple web app in a single Python file is as easy as it gets.
Pro Very flexible
Flask gives developers a lot of flexibility in how they develop their web applications.
For example, the choice of not having an ORM, but instead choosing one suited to the task, or another area where Flask gives a lot of options to developers is the templating. They can use Jinja2, Flask's default templating language or choose from a number of different templating languages they desire.
Pro Great documentation
The official documentation is very thorough and complete. Everything is explained in-depth and followed by extremely well-explained tutorials that tackle real-world problems.
Pro Able to use ORM or "true SQL"
Pro Grails is highly scalable
Grails is an abstraction over Spring and Hibernate. This makes Grails applications fast and scalable. This is because both Spring and Hibernate are themselves scalable.
Pro More than 900 plugins
Grails is a full-stack web framework, not just MVC. It contains a lot of stuff out of the box, but it doesn’t enforce it. It contains over 900 plugins which provide a Groovy API for a lot of useful and well-known Java libraries. And what is more important is that they are super easy to install!
Pro Very fast setup and scaffolding
Setting up a new project is quite fast and code generation (scaffolding) saves you a lot of time. It also uses a convention over configuration principle which helps you bypass all the configuration trouble.
Grails also comes with a reloading mechanism out of the box.
Pro Easy to use
Grails is designed to be a rapid development framework with a straight learning curve. It advocates convention over configuration. Extensibility is very simple when using plugins (there is a lot of them). One command in the console – and all the dependencies and configurations are managed for you.
Pro Great UI design alternatives
Do you need something advanced in the UI? You can either create it in GSP with an addon of CSS/JavaScript or you can find a plugin that will do the work for you. Plugins include integration with Bootstrap, jQuery, Yeoman and much more.
Pro Great documentation and community
The Documentation section is actually a wiki, which can be modified by any logged in user. It has an official manual, tutorials, screencasts, a sample app and much more. If that does not do it for you, then there are countless third-party tutorials, more than 12k questions on SO and much much more
Cons
Con Not async-friendly
Flask is explicitly not designed to handle async programming.
Con Setting up a large project requires some previous knowledge of the framework
Setting up a large project with Flask is not that easy considering how there's no "official" way of doing it. Blueprints are a useful tool in this regard but require some additional reading and are a bit tricky to get right for a beginner.
The lack of some defaults can also be problematic. Having to choose between different libraries for a certain task is never easy, especially if you have never worked with Flask before.
Con Threadlocals and globals used everywhere
The default way of creating applications in flask makes it hard to use reusable and clean code.
Con HTML-oriented, not API-oriented
Not necessarily designed for making APIs, though that is possible
Con Grails is a fairly complex framework
Grails is a pretty heavy piece of software. It's functionality is covered by GORM (Grails' Object Relational Mapping) which is a facade for hybernate and by Spring MVC.
Everything is glued by core Spring and furthermore, Grails adds another level of abstraction on top of all this. These things may create some trouble down the road when debugging.
Con Too obtuse and JVM centric
If you're a big fan of the JVM and have mastered all its goofy quirks, Grails might be a good choice, but there are other frameworks out there that are more straightforward and easier to use.