Flask vs Play

Flask is very easy to get up and going, with vanilla HTML or with bootstrap pieces. It doesn't take much lines of Python to load Flask to get headers working, etc, and since it's all modular you don't have to have something you don't want in your application.

Flask is one of the most popular Python web frameworks, if not the most popular one. As such, there's plenty of guides, tutorials, and libraries available for it. A large number of important Python libraries, such as SQLAlchemy have libraries for Flask, which add valuable bindings to make the development process and the integration between these libraries and Flask as easy as possible.

Even though it's pretty minimalistic out of the box, Flask still provides the necessary tools to build a quick prototype for a web app right after a fresh install. With all the main components pretty much packed in the flask package, building a simple web app in a single Python file is as easy as it gets.

Flask gives developers a lot of flexibility in how they develop their web applications.

For example, the choice of not having an ORM, but instead choosing one suited to the task, or another area where Flask gives a lot of options to developers is the templating. They can use Jinja2, Flask's default templating language or choose from a number of different templating languages they desire.

The official documentation is very thorough and complete. Everything is explained in-depth and followed by extremely well-explained tutorials that tackle real-world problems.

Play has quite a large community which provides numerous tutorials and videos related to developing with Play.
The Play official documentation covers many things, such as the framework itself but also specific stuff such as Akka, SBT and Netty.

There are also many big companies that base their main sites around Play, one of them is LinkedIn which provides third-party documentation on a regular basis.

Play framework's convention over configuration methodology makes most Play projects have a very similar structure. This means that the code written for the framework is very readable. This enables a developer to switch between applications without having to relearn the ecosystem for every project. The built-in templating system also helps with code and makes it possible to have a very low count of lines of code.

Play is very simple to get started. The documentation is very helpful for beginners and advanced users alike and the official website has a great "Getting Started" tutorial to begin developing with Play.

Play Framework is asynchronous from the bottom up: asynchronous is default in Play API.

Play uses Akka for concurrency, Scala for a templating engine, Netty as a client-server framework and SBT (Simple Build Tool) for building. And they all come out of the box.
Play also comes with the option to scaffold your applications. Play is an all-embracing ecosystem designed to increase developer productivity and shorten development times.