When comparing Inferno vs Metayota HTML Engine, the Slant community recommends Inferno for most people. In the question“What are the best React.js alternatives?” Inferno is ranked 9th while Metayota HTML Engine is ranked 21st. The most important reason people chose Inferno is:
Use it however you want in a framework of your own custom design. When things change in the industry, swap things out instead of being locked in by someone else's design.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Modular
Use it however you want in a framework of your own custom design. When things change in the industry, swap things out instead of being locked in by someone else's design.

Pro Pretty light-weight
Inferno weighs in at 9kb gzipped, which is light-weight.

Pro Fast performance
Inferno is one of the fastest UI libraries around and widely considered the fastest.
Pro React compatability
Using the Inferno compatibility package ("inferno-compat"), Inferno can support the vast majority of React codebases.
Pro Fast and leightweight
The framework is only approx. 10 kilobytes in size and 2k lines of code. The custom tags can be lazy-loaded or preloaded. The rendering process is fast and selective, so only updated elements are rendered.
Pro IDE for progamming
Metayota offers an IDE for programming or designing tags for this framework. There is no programming knowledge needed and all tags can be tested instantly.
Pro Clean Code / Clean HTML
Readable, easy to maintain and clean code. The Metayota HTML Engine does not add any non-standard HTML elements to your code or any unintended tags or attributes. The HTML can be written, like it was intended by the designer. Only elements which are finished with rendering are added to the DOM (no flickering).
Cons
Con Some React components may not work with Inferno
Inferno and React have different public and private APIs. If 3rd party components use a private API then it's almost certainly going to break when you use it with Inferno.
Once React Fiber is implemented, even libraries that are currently working will break and will not be supported by Inferno.

Con Not very popular
Which can hinder one's opinion of its future, but the future of all "frameworks" is to break things into smaller pieces, so inferno very well might get used by the big names in the future.
