When comparing Trisquel GNU/Linux vs GuixSD, the Slant community recommends Trisquel GNU/Linux for most people. In the question“What is the best OS that is mainly under a GNU license?” Trisquel GNU/Linux is ranked 1st while GuixSD is ranked 5th. The most important reason people chose Trisquel GNU/Linux is:
Fresh installation looks great.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Polished look and feel
Fresh installation looks great.
Pro Reliable and working great out-of-the-box
It works on many machines. Really good.
Pro Good but not so good
There's been a lot of effort put in this project through the years, there is no question about it. It's 100% free and it's very user-friendly, but it being based on Ubuntu 16.04 isn't the best thing, as you are working with software that still is actual but the versions are not the newest.
Pro Good for learning
For sure not the best one to be your main distro, but very good for learning as you can contribute to make this project to improve faster and then someday we will see the first stable release of this distro.
Pro Very modern concept distro
It has some interesting characteristics for the more technical users that could become a good contribution to the general GNU+Linux ecosystem.
Cons
Con Avoid proprietary-only GPU drivers
GPUs without libre drivers are a problem (not fault of Trisquel, of course). Also Wi-Fi cards in the same vein.
Con Loads to learn
New technologies demand new learning...
