When comparing PicoLisp vs Hy, the Slant community recommends Hy for most people. In the question“What are the best (productivity-enhancing, well-designed, and concise, rather than just popular or time-tested) programming languages?” Hy is ranked 43rd while PicoLisp is ranked 66th. The most important reason people chose Hy is:
Hy compiles to Python's abstract syntax trees. Python can import Hy modules, and Hy can import Python modules.
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Pros
Pro Integrated database and Prolog engine
Pro Fast code execution speed
One of the fastest code execution speeds compared to other Lisp dialects.
Pro Simplicity
Compared to other Lisp dialects, it's simple and doesn't have unnecessary features.
Pro Tacit
Code written in is short and easier to understand most of the time.
Pro Foreign function interface
The language has built-in FFI for C and also interfaces with java(via ersatz)
Pro Python interop
Hy compiles to Python's abstract syntax trees. Python can import Hy modules, and Hy can import Python modules.
Pro Easier to read
Distinguished between arrays (or vectors) and function calls by using [] and (), respectively.
Pro Copyfree and open source
Uses the MIT (expat) license.
Cons
Con Lack of Floating point data type
The language does not have floating point numbers only scaled fix-point numbers. Scaling of numbers is more work than directly working with floats.
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