When comparing MacPorts vs Alfred, the Slant community recommends Alfred for most people. In the question“What are the best power user tools for macOS?” Alfred is ranked 5th while MacPorts is ranked 41st. The most important reason people chose Alfred is:
Allows the creation of automated workflows by connecting keywords, hotkeys and actions together without writing code.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Provides a consistent experience across OS X versions
MacPorts eschews Apple-supplied libraries and links sources against its own making sure that the experience is the same regardless of what OS X version is used.
Pro Easy to use
Detailed instructions on the homepage are easy to follow. Official GUI app is also available
Pro Generally very up to date
MacPorts generally gets new software soon after it's available. This way users will not have to worry if their software is up to date.
Pro Nice variants system
MacPorts has a variants system that allows customizing builds with author provided options.
Pro Has many more packages than its competitors
As of this writing, 20K packages. 3 to 5x more than other current package managers.
Pro Requires SUDO to install apps
No need to worry if some rogue app will change your binaries or configuration.
Pro Download libraries instead of relying on Apple's caprices
Considering just how often Apple breaks things, any reduplication of of Apple-supplied libraries with the canonical sources is an asset.
Pro Fast
Written in Tcl & C, it's generally significantly faster than the competition. Tcl is also quite readable and comparable to Ruby, so it's also friendly to newcomers.
Pro Supports older Mac operating systems
Homebrew dropped support for old Macs. MacPorts still supports them.
Pro MacPorts is a native application: C + TCL
No need to install Ruby, or any other programming language.
Pro More packages than competition
Pro Apple Silicon Ready
With Apple moving over to its own silicon, macports has been ready for the move to ARM since 2.6.4
Pro Initially started and developed by Apple employees and supported by Apple itself
Reading the story behind MacPorts, it is the only one that was developed by Apple by an Apple employee. In fact it is the same person that was responsible for creating the FreeBSD port system.
Pro Great support for older systems
Pro Most of the available packages work
For example, trying to install Finch using Pkgsrc doesn't work, while installing it using MacPorts works perfectly. Finch isn't even on Homebrew's radar.
Pro Can create custom automated workflows
Allows the creation of automated workflows by connecting keywords, hotkeys and actions together without writing code.
Pro Full keyboard controls
You can do everything using just the keyboard.
Pro Built-in calculator
Alfred is able to handle simple mathematical commands and more extensive expressions alike. Pressing Enter copies the result to the clipboard.
Pro Integrates with 1Password
Alfred allows getting secure and fast access to your 1Password 1Click bookmarks.
Pro Lightweight and smooth
Alfred is a lightweight application for OS X and runs smoothly, even on older devices.
Pro Versatile search
Quickly search for files, applications and web services from the same input.
Pro Productivity booster
Helps speed up your working day one shortcut at a time.
Pro Clipboard history
Alfred offers a clipboard with an extensive history for quick access to your copied text, images and links.
Pro Entry of everything
Pro Allows theming
Alfred allows adjusting colors, fonts, sizes and more to create new themes.
Pro Offers both a free version and a paid version available
The paid version is more customizable, but the free version is still very powerful.
Cons
Con New Packages and Updates take time
Macports isn't the first choice for developers producing new packages or binaries for macOS. Nor is it the fastest in getting updates. But in general, it usually is one of the most up to date and will be updated eventually. Some would see this as a con in comparison to Homebrew.
Con Bad at limiting dependencies
MacPorts has a habit of pulling very specific versions of dependencies for each package. It downloads different version of already existing dependencies even in cases where the existing dependency version would have worked seamlessly.
Con Downloads unneeded libraries duplicating functionality already provided by Apple's libraries
As MacPorts eschews Apple-supplied libraries and links sources against its own a large duplication of functionality across MacPorts and Apple libraries can be found.

Con Requires root permissions (sudo) for installation of packages
A really good security feature, but some see it as a con.
Con Many features require the $25 powerpack add-on
Features like custom workflows, clipboard history, 1Password integrations and others require the powerpack add-on.
