When comparing pkgsrc vs Alfred, the Slant community recommends Alfred for most people. In the question“What are the best power user tools for macOS?” Alfred is ranked 5th while pkgsrc is ranked 62nd. The most important reason people chose Alfred is:
Allows the creation of automated workflows by connecting keywords, hotkeys and actions together without writing code.
Specs
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Pros
Pro pkgin is an apt-like tools for installing binaries from pkgsrc
pkgin aims to be a tool similar to apt/yum for managing pkgsrc binaries by relying on pkg_summary for installing, removing and upgrading packages and dependencies, using a remote repo.
Pro Adapted for use on over a dozen different operating systems
Has been adopted to be used on several Unix-like operating systems and Windows. It's also the default package manager of DragonflyBSD and of the (now discounted) Bluewall Linux distro.
Pro Installs and works in the same way as MacPorts
Installs its own dependencies which means that it is very secure. Cannot install anything unless you use the "sudo" command which is in keeping with the Unix philosophy.
Pro Both binary packages and source build possible
Fast software installation is possible by using binary packages. It's also easy to build from source which allows for different compile-time options (like different UI backends) as well as gaining access to pre-release versions of software in certain cases.
Pro Offering tooling for backporting fixes
Backporting fixes can be done by cherry-picking updates from a newer branch (pkgsrc is released every 3 months) and creating a package. Sometimes bugs need to be fixed for production and there is neither a fix in newer pkgsrc nor the softwares upstream. So pkgsrc has tools like pkgdiff, mkpatches, etc. that help with developing patches and building binary packages from that. A bit of documentation about that process can be found here.
Pro Does not need Xcode command line tools or Xcode.
This means that you can install it fresh on a new installation of MacOS and have all your favorite apps installed right from the start.
Pro Works easily with Ansible
Can be used from within Ansible to install packages on macOS.
Pro Easy installation if you use 3rd party scripts
This one works brilliantly.
Pro Can create custom automated workflows
Allows the creation of automated workflows by connecting keywords, hotkeys and actions together without writing code.
Pro Full keyboard controls
You can do everything using just the keyboard.
Pro Built-in calculator
Alfred is able to handle simple mathematical commands and more extensive expressions alike. Pressing Enter copies the result to the clipboard.
Pro Integrates with 1Password
Alfred allows getting secure and fast access to your 1Password 1Click bookmarks.
Pro Lightweight and smooth
Alfred is a lightweight application for OS X and runs smoothly, even on older devices.
Pro Versatile search
Quickly search for files, applications and web services from the same input.
Pro Productivity booster
Helps speed up your working day one shortcut at a time.
Pro Clipboard history
Alfred offers a clipboard with an extensive history for quick access to your copied text, images and links.
Pro Entry of everything
Pro Allows theming
Alfred allows adjusting colors, fonts, sizes and more to create new themes.
Pro Offers both a free version and a paid version available
The paid version is more customizable, but the free version is still very powerful.
Cons
Con Relatively complicated setup and installation
Installing and setting pkgsrc up is a bit more complicated than in other package managers where it often consists in running a single script.
Con Not so broadly used on MacOS as compared with MacPorts
You do not hear about Pkgsrc as openly as you hear the words "HomeBrew" or "MacPorts".
Con Outdated packages
Some packages are outdated.
Con Can't install some packages
Even building well known packages (except MacPorts) from source using the ports can fail.
Con Many features require the $25 powerpack add-on
Features like custom workflows, clipboard history, 1Password integrations and others require the powerpack add-on.