When comparing Colemak vs Colemak Mod-DH, the Slant community recommends Colemak for most people. In the question“What are the best keyboard layouts for programming?” Colemak is ranked 1st while Colemak Mod-DH is ranked 3rd.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Much more comfortable than QWERTY when touch typing
Pro Highly ergonomic
Pro You can type faster
Because the home row contains more high used frequency characters.

Pro AZXCV don't move compared to QWERTY
If you rely on the Control-A/X/C/V shortcuts (select all, cut, copy, paste), these keys don't move from their QWERTY locations.

Pro Relatively quick to learn
If coming from QWERTY, only a couple of keys move between hands.
Pro Optimized for quick two-letter bigrams
Not only are the most common English letters on home row under your fingers, but many common two-letter combinations are placed next to each other as well allowing for a fluid "inward roll" motion of letter combos (a-r, r-s, s-t, n-e, e-i, and i-o combos). The inward roll motion is debatably speedier than optimizing finger alternation like Dvorak offers.
Pro Backspace is closer
While the uncommonly used caps lock is further away. May be problematic if you previously developed muscle memory of using caps lock as some other key.
Pro Possibly faster
Most people like the common home row and believes it improves speed in comparison to QWERTY.
Pro Multilingual support
Although it‘s optimized for English, the support for a wide range of special characters enables occasional use of other languages. Still, the Carpalx research shows that a significant improvement is also present in Dutch compared to Qwerty. http://mkweb.bcgsc.ca/carpalx/?de_correspondent
Pro Much less lateral hand movement compared with regular Colemak
Some people find moving D and H to the bottom row much more comfortable (especially with flat keyboards). Curved keyboards like the Kinesis Advantage also help with lateral motion. Regular Colemak on these keyboards might be the ideal solution since then you help resolve some of the cons of regular Colemak without adding on the ones from Mod DH.
Pro Easy to learn from Colemak
No keys change fingers from Colemak (with the possible exception of Z , which is rarely used, in one variant).
Pro 'HE' easier to type compared with regular Colemak
Pro Letter G goes back to its original QWERTY position
This puts ING all on the middle row. Regular Colemak has G in the top row.
Cons
Con Bad for Vim users
Vim was designed on QWERTY. The HJKL "arrow" keys still work in Dvorak, but their positions make less sense in Colemak.
Con Overrated
People think Colemak is great because it is easier to learn, but in reality they are deluding themselves thinking that it is better than more advanced alternative layouts.
Con Designed for English
Like Dvorak, this layout privileges English letter frequency, and lacks accented letters.
Since the topic is about programming, the argument is weak as most code is written in English, yet you don't want to learn a layout to type code, and another to type in your native language...
But the problem isn't specific to Colemak, it is tied to all "ergonomic" layouts, and might have no solution.
Con The "HE" bigram is awkward
For all of Colemak's focus on optimizing English bigrams, the second-most used English bigram, "HE", is still kind of awkward due to same-hand lateral motion. This bigram is much easier in both QWERTY and Dvorak. If your concern is RSI, Colemak isn't good enough.
Con AZXCV don't move compared to QWERTY
This will allow one to intuitively access popular shortcuts, but the truth is that the placement of these keys is a compromise in terms of actual typing ergonomics.
Con Regular Colemak is more standard
Mac and Linux have regular Colemak keyboard options. This isn't an issue if your keyboard is programmable through QMK, VIA, etc.
Con H, M, V, B change from original QWERTY position
Regular Colemak has these in their original QWERTY position. The learning curve increases somewhat in Mod-DH.
Con Breaks up ZXCV slightly
Breaks up ZXCV (moves V over one space). Could cause copy paste confusion if also using other layouts like QWERTY. For ANSI layouts the Z is also moved to a new position.
Con No Innate Layout Configuration In Keybr
Keybr supports Standard Colemak but in order to adjust to DH Mod you must use an extension like tampermonkey and run a Script like this one and adjust to fit whichever variant.
Con Index fingers jump rows more often
Con More optimized for ISO and ortholinear style keyboards, not ANSI
