When comparing Base16 family vs Dracula, the Slant community recommends Dracula for most people. In the question“What are the best VIM color-schemes?” Dracula is ranked 3rd while Base16 family is ranked 8th. The most important reason people chose Dracula is:
Sublime, Atom, Vim, iTerm, Terminal.app, Zsh, Slack, TextMate, Emacs, Visual Studio Code/Visual Studio, Xcode, IntelliJ, and more.
Ranked in these QuestionsQuestion Ranking
Pros
Pro Contains many color-schemes
Pro Out of the box support for many applications (vim, terminals, etc...)
Base16 template repositories on github have configurations for most popular applications where a color scheme can be applied. This reduces headache for users when applying or switching color schemes.
Pro Its Solarized Dark scheme is compatible with htop
This is just one example of an app that doesn't work with vanilla Solarized Dark (half of the usernames in htop have the same color as the background)
One has to use a patched htop version.
Pro Available for many popular editors, terminals, etc.
Sublime, Atom, Vim, iTerm, Terminal.app, Zsh, Slack, TextMate, Emacs, Visual Studio Code/Visual Studio, Xcode, IntelliJ, and more.
Pro Great in lots of languages
Even for Markdown.
Pro Perfect color pitch
Colors are perfectly pitched, easy to focus on scripts and shells.
Pro Well designed
Pro Very good for the eyes
It looks very good, with a little of blue light. It also works very well with MacOS's Night Shift. I would recommend this theme for starters.
Cons
Con Schemes are limited to 16 colors
You may not be able to use as many colors as you want for a particular application without manual manipulation since base 16 color schemes are limited to 16 colors.
Con Each theme needs manual tweaking
The base16 color schemes are really great but as a vim theme they require a lot of manual tweaking to be viable. One example is that in one theme a neon green bg is used with a white fd rendering any part of the vim UI that uses those two colors together illegible.
Con Consistency
Some colors are too vibrant and bright.
Con Hard on eyes
