When comparing VLC vs Musique, the Slant community recommends Musique for most people. In the question“What are the best audio players for UNIX-like systems?” Musique is ranked 11th while VLC is ranked 13th.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Free, open source, and cross-platform
VLC is licensed under the CC-SA v3.0+ and available on Windows, OSX, and Linux with source code available here.

Pro Simple to setup and use
VLC is an incredibly robust application but very simple on the surface. It makes playing music simple, yet still manages to give the user all the tools he/she wants in a music player.
Pro Very versatile and easy to use
Pro Doesn't require additional codecs
Everything VLC needs to play media files is contained within which means no outside codecs are needed. This makes it one of the most hassle-free music players as it can play virtually anything as soon as it's installed.
Pro Tons of advanced settings
Besides basic configurations, video player has an extensive amount of adjustable settings.
Pro Doesn't manage your music library for you
You organize your music into folders any way you want. Want to play an album? Drag and drop. No tags, no confusion, no fluff. Easy.
Pro Can be almost completely keyboard-driven
VLC includes keyboard shortcuts for most actions. The video player can be controlled with simple and customizable keyboard commands.
Pro Surprisingly Lightest on Resources
Yes. Lightest. Even better than the ones known to be light. Both when playing music, only a single song or when playing a video. Either in terms of Ram and Cpu. Compared with almost all, including the ones from Windows like mpc-hc .. or light ones from Linux like Alsa Player, Audacious, SmPlayer .
Pro Can play every format video available (as of 2017)
Pro Supports a GUI interface and an ncurses terminal interface
Pro Can easily stream music across your home network from any device on the network
Using sftp/ssh music (and videos) can be streamed from any server on the network to any device running VLC. VLC can also be used as a webcam for streaming and snapshots. Amazing all in one package
Pro Large amount of extensions
VLC has a large amount of extensions.
Pro Can handle very large local music libraries
Pro Minimal UI
The UI for Musique is pretty minimal. By not throwing every option in the book into the application, the developers are able to keep the interface clear of any clutter.
Pro Consistent queue simplifies what's playing next
There is a queue on the right side of the player, which shows you what is coming up next. This makes it easy to add a new song or remove a song before it plays to be sure that you/your guests stay in the groove. You can also slowly transition to different genres, not to mention plan ahead and adapt as you need to.
Cons

Con Not really meant to be a music player
VLC is made to be a video player. Therefore, it won't carry out actions such as managing your music library.
Con Lacks libraries and advanced music player features
VLC is a media player first and foremost. There is no library management (aside from playlists), limited usage of tags, and no rating system. VLC is best at playing a file directly from a folder, but falls behind when it comes to helping you manage or find good songs in your music library.
Con Absence of personalization
VLC Player has only one basic interface in white or black, and overall personalization opportunities are quite narrow. Unfortunately, you're pretty much stuck to the default look.
Con Contains some insignificant but irritating flaws
Despite all keyboard shortcuts, the width of the picture can't be controlled by trackpad. Besides that, the VLC start-up window doesn’t open at the same place or the same width at which it was previously closed.
Con No differentation between Album Artist / Track Artist
Albums are sorted via "Album Artist" but each deviating "Track Artist" creates a new album handle. Very bad when you have album tracks where the filename consists of the typical "Artist #1 feat. Artist #2" setting as each of these files creates another album entry.
Con Doesn't resume from last close
Musique won't resume from the last time the app was closed. If you had a great music queue all set up, unfortunately it won't stay there if you close the app.
Con Linux controls don't work
The Linux next/previous buttons don't do anything - you will need to open Musique in order to do anything with it (other than change the volume).
