When comparing Tessel 2 vs NanoPi M4, the Slant community recommends Tessel 2 for most people. In the question“What are the best single-board computers?” Tessel 2 is ranked 36th while NanoPi M4 is ranked 54th. The most important reason people chose Tessel 2 is:
Out of the box it supports Node 4.x LTS and doesn't require any setup to use it.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro NodeJS support out of the box
Out of the box it supports Node 4.x LTS and doesn't require any setup to use it.
Pro Co-processor system
Runs Linux and user application code on a 580MHz Mediatek router-on-a-chip, with an asynchronous 48MHz SAMD21 coprocessor for GPIO, ADC, I2C, SPI, PWM and UART programming
Pro Programmable via USB or Wifi
The process for deploying software, whether it's JavaScript, Python or Rust, is exposed the same way for both USB and Wifi connections.
Pro Easy to get started with
The Tessel 2's "Getting Started" experience requires little more than installing Node.js and a single package (the CLI) via npm. Complete walkthroughs for Linux, Mac and Windows are available and up-to-date
Pro 6 core HexaCore, compact nvme extender, 4GB RAM
Pro Open Source
Works with mainline Linux kernel and open source Mesa Panfrost drivers.
Pro Many ports
4 x USB3
2 x USB2 available via pins
PCI-E available via pins
Pro Fast
Rockchip 3399 with two fast A72 cores. Good heatsink limites throttling.
Cons
Con Very little memory
64 megabytes of RAM. This places it more in line with an Arduino style board than a SBC on the level of Raspberry Pi.
Con Bleeding edge...
To have mainline kernel requires a bit of tinkering (e.g. installing Armbian). Panfrost drivers for 3d acceleration are not mature and crash sometimes...