When comparing Tkinter vs Xojo, the Slant community recommends Tkinter for most people. In the question“What are the best cross-platform GUI toolkits?” Tkinter is ranked 20th while Xojo is ranked 29th.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Free for commercial use
Pro Included in the standard Python library
You probably already have it, since it's included in the standard Python distributions.
Pro Easy to learn and get productive with
TkInter is a small library with a gentle learning curve compared to what’s out there. It has a straightforward API and is often the go-to choice for building quick GUIs for Python scripts.
Pro Building executables is less complicated
Compared to other GUI libraries, building executables for TkInter applications are simpler because TkInter is included in Python and has no other dependencies. This results in less complicated packaging requirements and smaller binary size.
Pro Fast
Pro Easy to use
Easy to make compiled native apps.
Cons
Con No advanced widgets
TkInter does not come with advanced widgets out of the box (e.g. date picker).
Con Not good looking
You need a lot of code to make it look good.
Con No reliable UI builder available
There is no tool in the same league as Qt Designer (PyQt) for TkInter.
Con Subscription-based/Not free
Using this product you're betting the company will still be around. If they get bought out by an enterprise that wants to use the tech internally, all they need to do is stop offering subscriptions and suddenly you're scrambling to rebuild your entire app on other technology.
Con No Android support
They plan to eventually support Android, but for now, they only support iOS.