When comparing F.lux vs SizeUp, the Slant community recommends F.lux for most people. In the question“What are the best power user tools for macOS?” F.lux is ranked 26th while SizeUp is ranked 57th. The most important reason people chose F.lux is:
Helps provide better sleep for more energy during the day.
Ranked in these QuestionsQuestion Ranking
Pros
Pro Can help sleep better
Helps provide better sleep for more energy during the day.
Pro Eases eye strain
Decreases color temperature at night, changing the normally fluorescent blue of an LCD monitor to a soft orange. Much easier on the eyes, especially in a low-light environment.
Pro Subtle transition
The transition from daytime to nighttime color modes takes an hour by default and will detect your current timezone, meaning that it will happen in the background at sunset, often without you noticing.

Pro Keyboard centric
SizeUp has user-configurable keyboard shortcuts for a set of pre-defined actions.
Pro Supports multiple monitors / spaces
Windows can be sent to different monitors and spaces. It can also be aligned as needed.

Pro Simple
SizeUp is easy and simple to use without having to configure.
Pro AppleScript support allows extending functionality
AppleScript permits adding features such as tiling all open windows. Additionally, FastScripts it allows the user to add keyboard shortcuts to AppleScripts.
Pro Menubar dropdown for shortcuts
Learning a bunch of keyboard shortcuts right off the bat may be difficult to remember at first, which is why a menubar shortcut for the app exists with all the shortcuts listed.
Cons
Con Takes a while to get used to
After installing F.lux, the screen will look a lot more yellow. This takes about a week to fully get used to. You can ease into it by setting the color temps higher than the recommended defaults.
Con Nag window
If a license is not purchased there is a nag window (which suspends function) that pops up when loading the app (at user login). The nag pop-up is also summoned at certain time intervals and by performing a certain number of commands (manually or by keyboard shortcut).
Con No on-the-fly split screen window settings
Unlike some other tiling window managers, SizeUp has no way to change the size of split screen actions on-the-fly. Any time a user wants to change how much room on the screen a window takes up when using the split screen function, they will need to manually change the settings, which can be time consuming.
