When comparing PaintCAD 4Windows vs Pyxel Edit, the Slant community recommends Pyxel Edit for most people. In the question“What are the best pixel art / sprite editors?” Pyxel Edit is ranked 6th while PaintCAD 4Windows is ranked 28th. The most important reason people chose Pyxel Edit is:
Tiles can be animated within Pyxel Edit, with "onion skin" frame overlays to assist in making smooth frame transitions.
Specs
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Pros
Pro Doesn't need to be installed
Simply download package, unpack, and use: no installation/setup/registry are required. Furthermore, all settings are saved in its own folder.
Pro You can draw images using the keyboard alone
The cursor on the image allows you to move it to any pixel of your image and place colored pixels precisely. You can draw on a small notebook (when travelling on a train or bus, for example), or in any other situation where you don't have access to a mouse.
Pro Completely free to use
All the user has to do is download the software and put it to use: draw images, create animations (gif), videos (avi), tilemaps, draw raster PCF fonts, and use it on your images for free!
Pro Support for Russian and English
The interface and help system have two localizations (English and Russian) included in the distributive package.
Pro Works with every Windows version
PaintCAD 4Windows doesn't need any .net, java, or other VM installed: it is a pure Windows 32-bit application and will work on every Windows-based operating system starting from Windows 95 until Windows 10.
Pro Supports animations
Tiles can be animated within Pyxel Edit, with "onion skin" frame overlays to assist in making smooth frame transitions.
Pro Intuitive UI
Pyxel Edit is widely acclaimed for its ease of use.
Pro Tileset extraction
Given an image and specified tile dimensions, Pyxel Edit will extract a tileset with no duplicate tiles. This mostly works for flat images though. If you feed Pyxel "finished maps" you will still get a lot of duplicates.
Pro Tilemap serialization support
Tile-based images (maps) built in Pyxel Edit can be serialized via XML or JSON for easy import elsewhere.
Pro Cheap compared to others
For only $9 (£6), this is one of the cheapest but also one of the best pixel editors out there.
Pro Live tile-update
Instantly see if your tiles are tileable and/or seamless and fix it easily.
Pro Indexed tiles can be used for reusing objects in animations
Cons
Con development has stopped -- developer has stated 8/20 that a new version will be released soon
Con Lacks some tools
Con No Linux version
There is no Linux version of the editor.
Con Free version lacks features
The free version of Pyxel Edit is an outdated beta. It does not receive updates.
Con Proprietary, closed-source software
This software does not respect your freedom.
Con Mac version is dependent on Adobe Air
The OSX version of the application requires Adobe Air to run.