When comparing Slate vs SizeUp, the Slant community recommends Slate for most people. In the question“What are the best power user tools for macOS?” Slate is ranked 21st while SizeUp is ranked 57th. The most important reason people chose Slate is:
Slate is similar to Linux WMs like Xmonad in that it is nearly infinitely configurable. You can either use the default configuration file or just Javascript for very complex/dynamic settings. Slate also offers editing a ".js" or a ".slate" file for configuration.
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Pros
Pro Extremely configurable
Slate is similar to Linux WMs like Xmonad in that it is nearly infinitely configurable. You can either use the default configuration file or just Javascript for very complex/dynamic settings. Slate also offers editing a ".js" or a ".slate" file for configuration.
Pro Based on hotkeys
Hotkeys can be set to re-size and focus windows, as well as activate layout presets.
Pro It's free
Slate is completely free to download and use, which is a great option in a field of Mac WMs that often costs money to use.
Pro Allows for tiling
Slate allows for customizing the config file in order to emulate tiling windows.
Pro Lets you set default layouts
By using a feature called "snapshots", users can set up different default window layouts in Slate that they can switch to and from on the fly.
Pro Window hints
Slate offers window hints which are an intuitive way to change window focus.

Pro Keyboard centric
SizeUp has user-configurable keyboard shortcuts for a set of pre-defined actions.
Pro Supports multiple monitors / spaces
Windows can be sent to different monitors and spaces. It can also be aligned as needed.

Pro Simple
SizeUp is easy and simple to use without having to configure.
Pro AppleScript support allows extending functionality
AppleScript permits adding features such as tiling all open windows. Additionally, FastScripts it allows the user to add keyboard shortcuts to AppleScripts.
Pro Menubar dropdown for shortcuts
Learning a bunch of keyboard shortcuts right off the bat may be difficult to remember at first, which is why a menubar shortcut for the app exists with all the shortcuts listed.
Cons
Con Project is no longer in development
Development is no longer active on this project as of 2017.
Con Hard to configure
There's no graphical user interface for configuring Slate, meaning it has to be done from the command line interface or by editing a config file. This makes it somewhat difficult and time-consuming.
Con Missing features
Unable to perform all tasks of software it was meant to replace.
Can not move windows between 'Spaces' (virtual desktops).
Con Video fail
Demonstration video failed to highlight any of the advantages of the windowing system. Or at least, the advantages were so subtly intrinsic that no-one who didn't already use the system could appreciate them.
Con Nag window
If a license is not purchased there is a nag window (which suspends function) that pops up when loading the app (at user login). The nag pop-up is also summoned at certain time intervals and by performing a certain number of commands (manually or by keyboard shortcut).
Con No on-the-fly split screen window settings
Unlike some other tiling window managers, SizeUp has no way to change the size of split screen actions on-the-fly. Any time a user wants to change how much room on the screen a window takes up when using the split screen function, they will need to manually change the settings, which can be time consuming.
