When comparing ShiftIt vs SizeUp, the Slant community recommends ShiftIt for most people. In the question“What are the best power user tools for macOS?” ShiftIt is ranked 46th while SizeUp is ranked 57th. The most important reason people chose ShiftIt is:
ShiftIt is configured through a simple UI where you simply press the hotkeys you wish to map to a certain action.
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Pros
Pro Easy to configure
ShiftIt is configured through a simple UI where you simply press the hotkeys you wish to map to a certain action.
Pro Free
Pro Intuitive
ShiftIt is very straight-forward to use for most frequent usages.
Pro Open source
Pro Configuration can be committed to your personal dotfiles repository
Configuration winds up living in .hammerspoon/init.lua and .hammerspoon/Spoons/ShiftIt.lua. Very easy to track configuration changes.

Pro Keyboard centric
SizeUp has user-configurable keyboard shortcuts for a set of pre-defined actions.
Pro Supports multiple monitors / spaces
Windows can be sent to different monitors and spaces. It can also be aligned as needed.

Pro Simple
SizeUp is easy and simple to use without having to configure.
Pro AppleScript support allows extending functionality
AppleScript permits adding features such as tiling all open windows. Additionally, FastScripts it allows the user to add keyboard shortcuts to AppleScripts.
Pro Menubar dropdown for shortcuts
Learning a bunch of keyboard shortcuts right off the bat may be difficult to remember at first, which is why a menubar shortcut for the app exists with all the shortcuts listed.
Cons

Con A little slow
Similar to Spectacle, but it has a few more features, such as being able to pick the size adjustment increments. Spectacle was a little faster, though. Repeated size changes or moves in succession can cause it to wait for it to complete.

Con Imprecise when readjusting sizes
Con Doesn't support moving windows between workspaces
There's no way to move a window to a different workspace with hotkeys in ShiftIt.
Con Nag window
If a license is not purchased there is a nag window (which suspends function) that pops up when loading the app (at user login). The nag pop-up is also summoned at certain time intervals and by performing a certain number of commands (manually or by keyboard shortcut).
Con No on-the-fly split screen window settings
Unlike some other tiling window managers, SizeUp has no way to change the size of split screen actions on-the-fly. Any time a user wants to change how much room on the screen a window takes up when using the split screen function, they will need to manually change the settings, which can be time consuming.
