When comparing SizeUp vs Backblaze, the Slant community recommends Backblaze for most people. In the question“What are the best power user tools for macOS?” Backblaze is ranked 10th while SizeUp is ranked 57th. The most important reason people chose Backblaze is:
The default configuration includes everything except for system files to be backed up. That also includes external USB drives. This will work for most people. It can, of course, be customized to each person's liking.
Specs
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Pros
Pro Keyboard centric
SizeUp has user-configurable keyboard shortcuts for a set of pre-defined actions.
Pro Supports multiple monitors / spaces
Windows can be sent to different monitors and spaces. It can also be aligned as needed.
Pro Simple
SizeUp is easy and simple to use without having to configure.
Pro AppleScript support allows extending functionality
AppleScript permits adding features such as tiling all open windows. Additionally, FastScripts it allows the user to add keyboard shortcuts to AppleScripts.
Pro Menubar dropdown for shortcuts
Learning a bunch of keyboard shortcuts right off the bat may be difficult to remember at first, which is why a menubar shortcut for the app exists with all the shortcuts listed.
Pro Beginner-friendly defaults
The default configuration includes everything except for system files to be backed up. That also includes external USB drives. This will work for most people. It can, of course, be customized to each person's liking.
Pro No file size or traffic restrictions
There are no limitations of file size or amount of data you can upload. The $5/mo plan gets you unlimited cloud storage.
Pro Excellent restoration performance
Backblaze creates a zip file of all your files for you to download, thus decreasing the amount of data you need to download and increasing the speed of the download since it's one connection instead of multiple that need to be opened and closed for a list of files.
Pro Secure
AES encrypted files are transferred over a secure SSL connection.
Pro Download any backed-up files from any web browser
Some backup services like Carbonite require a client to be installed to restore files. Backblaze allows you to login and download any or all files from a web browser, meaning it also serves as an ad-hoc cloud storage platform.
Pro Users can order a physical copy of their data
You can have a flash drive or an external hard drive delivered to you. They cost $99 and $189 respectively.
Cons
Con Nag window
If a license is not purchased there is a nag window (which suspends function) that pops up when loading the app (at user login). The nag pop-up is also summoned at certain time intervals and by performing a certain number of commands (manually or by keyboard shortcut).
Con No on-the-fly split screen window settings
Unlike some other tiling window managers, SizeUp has no way to change the size of split screen actions on-the-fly. Any time a user wants to change how much room on the screen a window takes up when using the split screen function, they will need to manually change the settings, which can be time consuming.
Con No Linux support
There's no Linux client for Backblaze.
Con Pay extra to keep deleted files permanently
Additional $2/Month plus $0.005/GB/Month for files updated, changed, or deleted more than one year ago.
Con Backblaze does not support network (NAS) drives
If you use a thing like Drobo, Backblaze will not back it up.