When comparing SizeUp vs Parallels Desktop, the Slant community recommends SizeUp for most people. In the question“What are the best power user tools for macOS?” SizeUp is ranked 57th while Parallels Desktop is ranked 59th. The most important reason people chose SizeUp is:
SizeUp has user-configurable keyboard shortcuts for a set of pre-defined actions.
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Pros

Pro Keyboard centric
SizeUp has user-configurable keyboard shortcuts for a set of pre-defined actions.
Pro Supports multiple monitors / spaces
Windows can be sent to different monitors and spaces. It can also be aligned as needed.

Pro Simple
SizeUp is easy and simple to use without having to configure.
Pro AppleScript support allows extending functionality
AppleScript permits adding features such as tiling all open windows. Additionally, FastScripts it allows the user to add keyboard shortcuts to AppleScripts.
Pro Menubar dropdown for shortcuts
Learning a bunch of keyboard shortcuts right off the bat may be difficult to remember at first, which is why a menubar shortcut for the app exists with all the shortcuts listed.
Pro Best-in-class gaming performance
Compared to other VMs, Parallels has the best gaming performance. Still, a good framerate can only be achieved with games that have very low resource requirements. A much better option for resource intensive games is dual booting Windows (via Boot Camp).
Pro Easy to use
Parallels has an easy to learn and use UI. All important features are wizard based. It requires only a few clicks for the wizard to download and set up the latest Chrome OS, Windows or Linux build.
Pro Can run Windows apps as native OS X apps
Parallels has a "Coherence View" mode that allows running Windows applications as if they were native OS X apps. In this mode Windows is virtualized in background and Windows features like Jump Lists, Taskbar, Start Menu, etc can be embedded directly within OS X.
Pro Best integration ever
Cons
Con Nag window
If a license is not purchased there is a nag window (which suspends function) that pops up when loading the app (at user login). The nag pop-up is also summoned at certain time intervals and by performing a certain number of commands (manually or by keyboard shortcut).
Con No on-the-fly split screen window settings
Unlike some other tiling window managers, SizeUp has no way to change the size of split screen actions on-the-fly. Any time a user wants to change how much room on the screen a window takes up when using the split screen function, they will need to manually change the settings, which can be time consuming.
Con Very expensive
Parallels upgrades are very expensive. Even if I bough several versions of Parallels I will switch back to free VirtualBox as they even "invented" the Pro version - mainly doubled the price you have to pay each year to have the software updated.
Con Can't import OVA files
OVA files are useful because they include all of its supporting files. Unfortunately, Parallels doesn't support these useful files.
Con Requires buying a new version of the software with each new OS X release
Chances are that the same version of Parallels won't work with different OS X releases, requiring a separate purchase of Parallels for each OS X version.
Con Home edition doesn't work with Vagrant or Docker Machine
Make sure you purchase the Pro edition (the subscription) if you need command-line access to the hypervisor.
Con Can't export OVA files
One you use parallel you get trapped into a proprietary format.
Can't share disk blocks on two unrelated virtual machines (KSM for disk) too.
