When comparing Klein vs Zope, the Slant community recommends Zope for most people. In the question“What are the best general-purpose Python web frameworks usable in production sites?” Zope is ranked 10th while Klein is ranked 20th.
Ranked in these QuestionsQuestion Ranking
Pros
Pro More concurrent requests, more interactivity
The fact that a Klein server is event-driven and non-blocking means that it can start handling a new request while previous requests are still open. This lets you serve more requests from a single process, meaning running multiple servers is now an option to be explored when your site makes it big, rather than a necessity for responsiveness under even modest loads.
Multiple requests per process also gives you flexibility to do things that would be impractical in WSGI-based alternatives like Flask or Bottle, such as keeping a connection to the browser open to send it chat messages or game updates in a Server Sent Event stream.
Pro Mature framework
Cons
Con Lacks database integration
Talking to database is a pretty common thing for a web application to do. Larger frameworks know this, and cover it in some detail by the end of the tutorial. In contrast, the Klein documentation is currently silent on this topic, leaving the issue of how to do database queries in a way that won't block your event-driven code entirely up to you.