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Add to SafariWhen comparing Mu4e vs Sylpheed, the Slant community recommends Mu4e for most people. In the question“What are the best native e-mail clients for Linux?” Mu4e is ranked 10th while Sylpheed is ranked 16th. The most important reason people chose Mu4e is:
The UI is designed to allow for quick keystrokes to get around and is pretty clean. Header View:  Message View: 
Question Ranking
Pros
Pro UI optimized for speed
The UI is designed to allow for quick keystrokes to get around and is pretty clean.
Header View:
http://www.djcbsoftware.nl/code/mu/mu4e-2.png
Message View:
Pro Asynchronous
Heavy actions never block emacs, unlike most other emacs email clients.
Pro Fully Search Based
Mu4e has no folders or other organizational tools, rather it relies on very fast search queries to help you find your mail.
Pro Can write rich text emails
Using the (beta) org mode, Mu4e can compose fully rich text emails.
Pro Built-in Autocomplete
Doesn't require you to import address books for autocomplete, learns from your emails just like Gmail.
Pro Reliable
No issues with stability or stuff going missing.
Pro Comprehensive settings
Pro Very very lightweight
It is simple and very lightweight where claws mail added a lot of bloat like themes and plugins slypheed keeps it simple.
Cons
Con No encrypted mailbox
Likely hasn't been done by anyone since Calypso/Courier back in the 00's.
