Mustache.js vs React
When comparing Mustache.js vs React, the Slant community recommends Mustache.js for most people. In the question“What are the best JavaScript templating engines?” Mustache.js is ranked 4th while React is ranked 8th. The most important reason people chose Mustache.js is:
Mustache provides you with a clean and easy to understand syntax. Having a syntax that is readable is always a huge plus, since this means easier maintenance and code readability in the future.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Clean syntax
Mustache provides you with a clean and easy to understand syntax. Having a syntax that is readable is always a huge plus, since this means easier maintenance and code readability in the future.
Pro Available in lots of languages
Available in a wide variety of languages including Ruby, JavaScript, Python, C++, Scala, Go, Julia, Swift and more. See the full list here.

Pro Lightweight
Mustache is easy to deliver. If you need more features down the road, you can switch to handlebars, which is a superset of Mustache.
Pro Logic-less
By design logic-less templates force you to separate concerns thus helping you avoid future problems with refactoring. It also allow templates to be used with multiple programming languages without changes.
Pro Server side support
Mustache.js has multi-language server side support, which essentially means you can use mustache based templates on languages other than javascript. (like if your server-side was built on Java you could still use Mustache.js)
Pro Popular
This would mean that you'll have a large community to help you out if you run into any problems.
Pro Can be compiled
Mustache templates can be compiled to JS files, so that they can be directly loaded.
Pro Easy to reuse components
Since every single UI component is created independently in JavaScript, it becomes very easy to reuse them throughout your app without having to re-write them.
Pro Supported by Facebook and Instagram
React is built by Facebook engineers initially to be used only for their inner projects especially to solve the problem of building large complex applications with constantly changing data.
Pro Server side rendering
React can render it's components and data server side, then it sends those components as HTML to the browser.
This ensures faster initial loading time and SEO friendliness out of the box, since it's indexed as any other static website by search engines.
Pro Virtual DOM support
Instead of relying on the DOM, React implements a virtual DOM from scratch, allowing it to calculate precisely what needs to be patched during the next screen refresh. This is orders of magnitude faster than fiddling with the DOM itself.
Pro One-way data flow
React's one-way data binding (or one-way data flow) means that it's easy to see where and how your UI is updated and where you need to make changes. It's also very easy to keep everything modular, fast and well-organized.
Pro Can be used with different libraries
ReactJS can be used independently as the only library for building the front-end, or it can be used alongside JavaScript libraries such as jQuery, or even Angular.
Pro Template engine independent
React provides a template engine (JSX) which is easy to use. But it's not mandatory.
Pro Widely used
The framework is widely used in the industry.
Pro Functional programming style leads to less buggy UIs
Pro Easy to write tests
Since React's virtual DOM system is implemented completely in JavaScript, it's very easy to write UI test cases.
Pro Good debugging tools
React has an official Chrome Extension which is used as a developing and debugging tool. It can be used to quickly and painlessly debug your application or view the whole application structure as it's rendered.
Pro Flux architecture pattern
Flux is a platform agnostic pattern which can technically be used with any application or programming language.
One of Flux' main features is that it enforces uni-directional data flow which means that views do not change the data directly.
With React this is useful because this way it's easier to understand an application as it starts getting more complicated. By having two-way data binding, lead to unpredictable changes, where changing one model's data would end up updating another model. By using the Flux architecture, this can be avoided.
Pro Extensive SVG support
Since React v0.15, SVG is fully supported. React supports all SVG attributes that are recognized by today's browsers.
Pro Keep control over your app's logic
React is just a view library, so you still have (almost) full control over how your app behaves.
Pro Supported by ClojureScript libraries
Reagent, Om, Rum, etc.
Pro Tested on Facebook itself
React is used on one of the most visited websites on the planet, Facebook. With stellar results and with millions of people experiencing it every day.
Cons
Con Basic tasks are difficult
Mustache js's attempts at making some things simple makes them so easy that they're almost difficult. That is the case with some basic tasks like figuring out how to apply css to shade odd/even rows on your template based content.

Con Bested by Handlebars in many ways
Handlebars being an extension of Mustache bests it in both speed and power. It adds additional features to Mustache which make writing templates easier and faster.
Benchmarks have also shown that Precompiled Handlebars renders in about half the time of Mustache and the rewritten Handlebars (current version) is 5 to 7 times faster than Mustache.
Con Heavy on memory
React's virtual DOM is fast, but it requires storing elements in the virtual and real DOM increasing memory usage for the page. This can be a real problem for single-page webapps designed to be left running in the background.
Con Template(view) mixed into code
Con Verbose
React gets a little verbose as applications get more complicated with more components. It's simply not as straightforward as simply writing HTML and JavaScript would be.
Con You have to learn a new syntax
Requires learning a custom syntax, JSX, that has some gotchas and introduce complexity, a steeper learning curve, and incompatibility with other tools.
Though you can opt out from JSX and use vanilla JS instead. But that is not recommended since it adds a lot of unneeded complexity which JSX tries to avoid.
Con Not a complete solution
React does not do everything for the developer, it's merely a tool for building the UI of a web app. It does not have support for routing or models, at least not out of the box. While some missing features can be added through libraries, to start using React and use it in production, you still would need to have experience, or at least a good grasp on what the best libraries to use would be.
Con Large file size
React's react.min.js
is 145.5KB in size. It's much larger than some other libraries that offer roughly the same features and it's almost the same size as some MV* frameworks such as Angular or Ember that offer more features out of the box.
Although, it should be mentioned that sometimes having a smaller library may force developers to reinvent the wheel and write inefficient implementations on features that React already has. Ending up with a larger application that's harder to maintain and/or that has bad performance.
Con Renders too frequently
Con No support for legacy browsers
React has recently dropped support for Internet Explorer 8. While the library may still work on IE8, issues that affect only IE8 will not be prioritized and/or solved.
