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When comparing PySide vs Dear PyGui, the Slant community recommends Dear PyGui for most people. In the question“What are the best Python GUI frameworks/toolkits?” Dear PyGui is ranked 5th while PySide is ranked 7th.
Specs
Question Ranking
Pros
Pro Supported by the Qt Company
Qt for Python aka PySide2 is the official set of Python bindings supported by the Qt Company.
Pro Qt widgets
Possibility to use a traditional widget-based user interface.
Pro QtQuick/QML
Possibility to use a declarative approach to define the user interface.
Pro Weak copyleft
PySide is licensed under the LGPL, which makes it easier to incorporate into commercial projects than PyQt.
Pro Easy to use
Pro Multi-purpose
Even while it's in beta, there's a ton of stuff that can be done with this framework.
Pro Helpful and responsive community
Pro Great performance
It's fast and responsive due to being written in C++, using the GPU and it is asynchronous by default.
Pro Smooth and easy to scale with a project
Pro Permissive MIT license
Pro Pythonic API
Despite originating from C/C++, DPG is the most Pythonic framework out there.
Pro Open source
Pro No GUI lag
GUI and Python API run at separate thread automatically!
Cons
Con Similar to PyQt, you need a C++ background. at least you can read C++ code
Qt's document is poor, and Qt for Python(PySdie) is even worse. this document assumes that you are already familiar with Qt. if you want to customize a Widget, you need to look at the Qt C++ source code to know what to do.
Con Community is still very small
