When comparing SmoothMoves vs Demina, the Slant community recommends SmoothMoves for most people. In the question“What are the best 2D skeletal animation tools?” SmoothMoves is ranked 12th while Demina is ranked 14th. The most important reason people chose SmoothMoves is:
Developers echo17 provide Playmaker action scripts for SmoothMoves.
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Pros

Pro PlayMaker integration
Developers echo17 provide Playmaker action scripts for SmoothMoves.

Pro Texture swapping and tinting at runtime
Animations can be re-skinned in several ways, entirely on the fly.

Pro Straightforward tutorials
Denima's user interface is very simple, and the primary documentation is a simple walk-through of the workflow.


Pro Open source
Demina is a C#/XNA application hosted on CodePlex under the Microsoft Public License.
Cons

Con Bone hierarchy is not collapsible
When working with a complex skeleton, the entire tree is always visible. There is no way to hide bones under their parents.

Con Unity Middleware
SmoothMoves is not a stand-alone application. It runs entirely within the Unity Editor, and is not compatible with other engines.

Con No longer under development
The most recent update to Denima occurred in October 2012.

Con XNA-specific
Denima's runtime library is intended to integrate with the XNA framework, which has been unsupported since April 2014.
