When comparing Demina vs Anima2D, the Slant community recommends Anima2D for most people. In the question“What are the best 2D skeletal animation tools?” Anima2D is ranked 4th while Demina is ranked 14th. The most important reason people chose Anima2D is:
Everything you could want from a skeletal animation system, free and because purchased by unity promises to be native in future.
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Pros

Pro Straightforward tutorials
Denima's user interface is very simple, and the primary documentation is a simple walk-through of the workflow.


Pro Open source
Demina is a C#/XNA application hosted on CodePlex under the Microsoft Public License.
Pro Purchased by unity
Everything you could want from a skeletal animation system, free and because purchased by unity promises to be native in future.
Pro Free
Pro Spring bones
Much like spring joints native to unity, you can set bones to have dynamic spring animations based on their parents.
Cons

Con No longer under development
The most recent update to Denima occurred in October 2012.

Con XNA-specific
Denima's runtime library is intended to integrate with the XNA framework, which has been unsupported since April 2014.
Con No longer supported by Unity.
This has been merged into the 2D Animation package.
Con Uses the Unity hierarchy
It's impossible to rename your asset after making your animation, otherwise you lose dependencies.
