When comparing Pixi.js vs TIC-80, the Slant community recommends TIC-80 for most people. In the question“What are the best 2D game engines?” TIC-80 is ranked 49th while Pixi.js is ranked 56th. The most important reason people chose TIC-80 is:
The app contains tools for coding, sprite editing, map editing, sfx and music editing.
Specs
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Pros
Pro Supports WebGL w/ canvas fallback
Pixi is a WebGL renderer, but can fall back to canvas if WebGL is not supported or turned off.
Pro Will be familiar to ActionScript developers
Pixi.js uses a code structure that's very similar to ActionScript.
Pro All tools in one place
The app contains tools for coding, sprite editing, map editing, sfx and music editing.
Pro Free
Free version already includes most features but a paid version is available.
Pro Retro-styled and restricted environment
Pixelated Software with a good retro style.
Pro Many Scripting languages' supported
Use awesome scripting languages like: Lua, Wren, Moonscript, JS, Ruby, etc.
Pro Export
Exports easily to Windows, Windows-XP, mac, Linux and HTML.
Pro Noob underdog
You can imagine this engine Shiva Lua scripting language making 2d side scrolling Megaman style games a Bandai trademark.
Cons
Con Not a complete solution
Pixi only provides the renderer.