When comparing Threema vs Skype, the Slant community recommends Threema for most people. In the question“What are the best messaging apps for Android?” Threema is ranked 6th while Skype is ranked 33rd. The most important reason people chose Threema is:
Registration is handled by random generated IDs. No phone number needed.
Specs
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Pros
Pro Registration without phone number
Registration is handled by random generated IDs. No phone number needed.
Pro Encrypted communication
Provides complete end-to-end encryption.
Pro Company behind Threema is based in Switzerland
Pro Servers in Switzerland
Privacy laws protect the data Threema has.
Pro Supports encrypted group chats
Pro Provides a web client
You can control and message with friends via Threema Web, the official web client for Threema.
Pro Ability to send pics and videos
Threema supports sending media messages such as video, pics and even voice messages.
Pro Group chat polls
Pro Allows verification of contacts identity via QR Code
Pro Easily connect with others due to how popular the service is
There's a good chance that whoever you're trying to reach has Skype already set up and familiar with it, avoiding the hassle of installing and getting to know new software.
Pro Screen sharing
You can show your whole desktop, a select part of the screen or a specific window over Skype.
Pro Cross-platform
There's software for Windows, Mac & Linux and apps are available on iPhone, Android, and Windows Phone.
Pro Group video for free
You can hold video calls with up to 10 people.
Pro Available on Linux
A stripped down, minimalist version of Skype is available for Linux.
Pro File sharing
Skype allows you to send any files (MP3s, images, text, etc.) by simply dragging and dropping then in the chat window making it simple to share things with colleagues.
Pro Cheap fixed phone number
Starting at $5/mo you can get a Skype number.
Pro Send SMS and make regular calls
With Skype Credit bought or a subscription, you can send SMS and make direct calls.
Pro Group chat with archive / records
Pro Powerful 1:1 chat and also group chat
Cons
Con Not free
Unlike many other options Threema is not free as it costs $1.99 for the app.
Con Single device only
You cannot use multiple devices to send messages. However, it does have message mirroring on a web client.
Con No cloud sync
E2E encryption means no cloud syncing of messages.
Con Plagued by bugs on all platforms
Crashes and other bugs are prevalent on Android, Windows and other platforms.
Con Subpar video quality with more than 5 users
Skype has significant problems with multiple users and video quality. Skype recommends that a max of 5 users group chat as video quality is severely affected. Even webcams tested with other chat services showed lower quality when used with Skype.
Con Not a feasible alternative as a professional team chat
Missing key feature such as centralized mgmt, centralized billing, data retention policies, ...
Con Poor quality when screensharing
It is not possible to manually set resolution or bitrate, and Skype often defaults to a resolution so low that text is unreadable. It is also not possible to transfer control over mouse and keyboard.
Con Slow filesharing speed

Con Owned by Microsoft
Con Obnoxiously large ads
Ads take up over 25% of the usable space.
Con Poor Linux support
The version available for linux users is quite outdated, and does not support some of the newer functionality, such as the free group video calling and screen sharing.
Con Requires both ends to be online (if neither end is using a cloud-enabled device)
Messages are sent and received only when both ends are online, if neither end is using a cloud-enabled device. In this case, if you are online 9-17 and your recipient is online 18-3, messages will never be delivered.
Con MIcrosoft (Skype's owner) actively assists eavesdroppers
On the other hand, if you lose your copy of one of your conversations, you may be able to get a copy of it from your government with a little bit of luck and a public records request.
