When comparing Antox vs qTox, the Slant community recommends qTox for most people. In the question“What is the best Tox frontend?” qTox is ranked 2nd while Antox is ranked 3rd. The most important reason people chose qTox is:
Can you even call it chatting now without emoji to inject context for potentially ambiguous statements? Avatars are great too for keeping track of who you're talking to since usernames are inscrutable hashes.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Free, open source
Antox is licensed under Creative Commons with source code available on GitHub. Being open source makes it possible to make sure your messaging are not controlled by a corporation.

Pro Peer-to-peer
There is no middleman, all communication happens between the users.
Pro Avatars and emoji
Can you even call it chatting now without emoji to inject context for potentially ambiguous statements? Avatars are great too for keeping track of who you're talking to since usernames are inscrutable hashes.
Pro Voice chat
Switching to voice chat is simple, though often fairly sensitive to network congestion with struggles to regain high-bitrates/audio clarity afterwards.
Pro File transfers
Sharing files is done between clients with the same encryption used for messages without any perceptible loss of speed.
Pro Group chats
Chatting with a group of people is no more complicated than the one-on-one conversations, without any need to re-join a "room" everytime you open the client as is done on IRC.
Pro Large variety of install packages
Releases for Linux distributions include native binary packages for Arch, Debian, Fedora, Gentoo, openSUSE and Ubuntu. Also available are Flatpaks and AppImages as well as tarballs, not to mention the more ubiquitous EXE and DMG files catering to Windows and MacOS users, respectively.
Pro Cross-platform
Windows, macOS, Linux.
Cons
Con High data usage
Antox uses the Tox protocol which is Peer to Peer, so there will be high data usage and battery drain. WiFi only mode is currently recommended for now.
Con Still in early development
Antox is still really early in development, being in beta currently.
Con Battery drain
Antox uses the Tox protocol which is Peer to Peer, so there will be high data usage and battery drain.
Con audio and video chat is not stable
