When comparing PyGObject / Python3 vs Dear PyGui, the Slant community recommends Dear PyGui for most people. In the question“What are the best Python GUI frameworks/toolkits?” Dear PyGui is ranked 5th while PyGObject / Python3 is ranked 12th.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Works particularly well on Linux, as many desktops use Python and GObject
GObject is a 'C' library with bindings to many other languages, so can be widely used.
Nice GTK.UIManager function to produce a menu system from a string.
Pro Easy to use
Pro Multi-purpose
Even while it's in beta, there's a ton of stuff that can be done with this framework.
Pro Helpful and responsive community
Pro Great performance
It's fast and responsive due to being written in C++, using the GPU and it is asynchronous by default.
Pro Smooth and easy to scale with a project
Pro Permissive MIT license
Pro Pythonic API
Despite originating from C/C++, DPG is the most Pythonic framework out there.
Pro Open source
Pro No GUI lag
GUI and Python API run at separate thread automatically!
Cons
Con Doesn't work well if you're targetting Windows, even though there probably is a binding
Not very close to Windows look and feel.