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When comparing Common Lisp vs Guile, the Slant community recommends Common Lisp for most people. In the question“What are the best Lisp dialects?” Common Lisp is ranked 3rd while Guile is ranked 4th. The most important reason people chose Common Lisp is:
Almost all aspects of the language are designed with interactive/repl use in mind.
Specs
Question Ranking
Pros
Pro Carefully designed for interactive use
Almost all aspects of the language are designed with interactive/repl use in mind.
Pro Very Powerful REPL with SLIME
SLIME (Superior Lisp Interaction Mode for Emacs).
Pro Condition/restart system
It is easy to recover from errors. Error resolution can be determined by the user at the REPL.
Pro Image based runtime
The state of the program may be saved and reloaded as an image, supporting safer modification of the running program. New code may be compiled into the image as the program runs, while late binding ensures that symbol redefinitions take effect throughout the program.
Pro Almost as fast as, or faster than, C
Some compilers such as SBCL can be faster than C or other low-level languages, and most compilers can generate fast native code.
Pro Easy to customize and extend applications
Guile makes it easy for users of your application to write extensions without needing to understand the plumbing of your program.
Pro GNU's official extension language
Chances are a system running enough GNU software will already have it installed.
Pro Excellent documentation
The documentation provides conceptual overviews, tutorials, and a detailed reference for all commands, functions, and operators.
Pro Fantastic interface to C, C++ in both directions, embedding guile in C/C++ and embedding C/C++ in guile
Cons
Con Weak copyleft
LGPL
