When comparing pyglet vs Nez, the Slant community recommends pyglet for most people. In the question“What are the best 2D game engines?” pyglet is ranked 43rd while Nez is ranked 89th. The most important reason people chose pyglet is:
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro 3D support
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Pro Cross-platform
Works with Windows, Linux, and OS X.
Pro Written in pure Python
A small advantage, but being a core Python developer, it may be the best to stick to the roots and develop with pyglet as it is able to compile using other Python interpreters.
Pro Active community
The community is very active, so if you ask for help you'll get it relatively quickly.
Pro Open source
Completely free, no need to pay for licenses.
Pro Cross-platform development thanks to the use of mono and xamarin
Nez is built on top of monoGame and can be used the make games for many platforms (Windows, Linux, Mac, Android or IOS).
Cons
Con Small community/popularity
There is a decent amount of documentation and API to go along with pyglet, but in terms of community support there seems to be very little.
Con Just a framework
Meaning there's no visual scene designer so you'll have to write your own.