When comparing PCLinuxOS vs Guix, the Slant community recommends Guix for most people. In the question“What are the best Linux distros that don't use systemd?” Guix is ranked 16th while PCLinuxOS is ranked 24th. The most important reason people chose Guix is:
For those with a clear focused concept of what is wanted, after building, the build can be replicated in a blink on countless machines. Both GUIX and shephard are complex but also a breath of fresh air.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Software management and updating made simple through Synaptic
Pro The team is headed by Texstar
One of the best in the business.

Pro Rolling release model
No reinstalling the OS after every major upgrade. Keep your OS updated, and you have the latest version.
Pro Helpful and knowledgeable forums
Many issues can be resolved by just searching the forums. They are really a storehouse of knowledge. If not, expert help is still available.

Pro "Batteries included" philosophy
Main release includes most apps needed by users everyday. Windows users will see a familiar look and feel to the UI. H/W issues practically nonexistent, as most drivers come with the ISO.
Pro Atomic package management without bloated init/supervision systems
For those with a clear focused concept of what is wanted, after building, the build can be replicated in a blink on countless machines. Both GUIX and shephard are complex but also a breath of fresh air.
Pro Secure rootless installation
While the whole system can be configured using a declarative file with sufficient privileges. Users can install any package in their own local profile with a single command without root.
Pro A truly advanced operating system
Solves modern problems of software management in one concise, coherent, and fully integrated system.
Cons

Con No 32-bit version

Con Gaming can be hit or miss
To run some titles, particularly from Steam, some "massaging" is necessary.
Con Not for newbies, neither for seasoned professionals, unless raging against conformity with artful purpose
