When comparing Tweetbot vs TweetDark, the Slant community recommends Tweetbot for most people. In the question“What are the best Twitter clients for OSX?” Tweetbot is ranked 1st while TweetDark is ranked 2nd.
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Pros
Pro Beautiful design
Pro Multiple accounts
Manage multiple accounts and get alerts for them.
Pro Dark Mode
Pro Excellent search features
Type your search term, then select whether you want to search for tweets that contain that term or go straight to the user whose name is the same as your search term.
Pro Keyboard shortcuts
cmd+n, shift+cmd+enter -- pretty much every time I've thought "maybe this is the shortcut for that" I've been right. Super intuitive.
Pro Multiple account support
Allows easy switching of accounts withing the app.
Pro Works also as a Facebook & FourSquare app
TweetDark combines Twitter, Facebook & FourSquare in one app.
Cons
Con The price is a subscription
It will end up horribly expensive.
Con Expensive
Con Missing features that exist on iOS
Con Ads
Free version has ads that can be removed by buying $5 premium version.