When comparing Garden (Clojure) vs cssnext, the Slant community recommends cssnext for most people. In the question“What are the best CSS preprocessors/postprocessors?” cssnext is ranked 5th while Garden (Clojure) is ranked 9th. The most important reason people chose cssnext is:
cssnext is a PostCSS plugin, which makes it pretty easy to use for people who are already using PostCSS.
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Pros
Pro Style webpages with a full programming language
With Garden, you have access to all the core features of a powerful programming language to build your scripts, including functions, variables, namespaces, and data manipulation like map merging or concatenation.
Pro Full-stack Clojure with ClojureScript for front-end + Clojure for backend
Garden finishes the full Clojure stack experience — you can have the entire codebase in a single language with ClojureScript on the front-end, Clojure on the backend, and Garden for CSS.
Pro Hot loading
Using the core Garden auto loader or the excellent Garden Gnome plugin, watch your style changes take effect in the browser as soon as you save the code — no reload required.
Pro Styles as data-nesting are obvious
Clojure is a data-oriented programming language with strong emphasis on simple, clear inline data structures. Garden models styles using these same structures, making the cascade visually obvious.
Pro Clean syntax
Other options listed include various pain-points like use of @ symbols or too much cruft; because Garden is just Clojure, and Clojure is a very well-designed language aimed to emphasize simplicity and positive developer experience (without semantic whitespace problems), you have the full benefit of a well-designed and general-purpose syntax.
Pro CSS-engine accessible from front-end
Because Garden is also Clojurescript friendly, this means that you can dynamically effect styles based on app state.

Pro Built on PostCSS
cssnext is a PostCSS plugin, which makes it pretty easy to use for people who are already using PostCSS.

Pro JavaScript-based
Because the parser/compiler can function in a web browser, it can be used with systems that cannot run similar technology on the server. For example, you could build a WordPress plugin with a front-end application that transforms CSS.
Pro No need to learn a new syntax
Since css-next only adds new CSS features in a way that all browsers can support it, it's still CSS. So there's no need to learn any new syntax.
Cons
Con Harder to apply shared styles
Because you are working in Clojure, you can't just paste in raw css style snippets shared elsewhere.
Con Lack of support in IDEs
Currently there is very little support for syntax highlighting when writing PostCSS plugins.
