When comparing Razer Lachesis vs Razer Mamba, the Slant community recommends Razer Mamba for most people. In the question“What is the best gaming mouse?” Razer Mamba is ranked 31st while Razer Lachesis is ranked 74th. The most important reason people chose Razer Mamba is:
Very comfortable, good weight and easy-to-program options (button functions, colors, etc).
Specs
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Pros
Pro Braided cable
Helps prevent kinking, curling and protects the cable prolonging life of mouse.
Pro Ambidextrous
The Razer Lachesis is an ambidextrous mouse.
Pro Shape and size good for medium to large hands
The Razer Lachesis is a great mouse for those with large hands. With the hump where the users palm rest being a bit further back than a lot fo other mice it makes a good fit for those large hands.
Pro Custom color lighting
Using Razers Synapse software users can customize their color lighting.
Pro On the fly DPI switching
There are two buttons under the scroll wheel that allow for on the fly DPI switching.

Pro Good design, good software
Very comfortable, good weight and easy-to-program options (button functions, colors, etc).
Pro Has wireless and wired options
The Razer Mamba is a wireless mouse that is also able to be wired by simply plugging in the provided USB cable.
Cons
Con Horrible lift-off distance
Lift-off distance is advertised as 1mm, which is not true, it's more than half an inch.
Con Unreliable drivers
The mouse freezes, lags and the mouse pointer might even die.
Con Unreliable CPI switcher
On-the-fly CPI scale resets, and sets to wrong settings often.

Con Battery life is very limited
Battery charge dies very quickly.
