When comparing Harrison Mixbus vs Sequel 3, the Slant community recommends Harrison Mixbus for most people. In the question“What are the best DAWs? ” Harrison Mixbus is ranked 17th while Sequel 3 is ranked 24th.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Has a great overall sound
Pro Great/intuitive interface
Many parts of the interface are designed as one function per control for ease and simplicity, and are modeled after physical consoles and mixer controls to further that end
Pro Based off of Ardour
Modified version of the open source Ardour DAW, with Harrison's proprietary interface and software tweaks
Pro In-Line/Built in analog summing
tube and transistor emulation, based on physical consoles made by Harrison
Pro Proprietary software that contributes to open source
provides features and bugfixes to upstream Ardour project, and also provides a portion of sales revenue to Ardour's development and administrative maintenance.
Pro Crossplatform
has support for Windows, Mac OS X, and Linux, for 32 and 64 bit. Works with CoreAudio, ASIO, and ALSA, as well as integrated 3rd party/open source routing software support, I.E. jackd on Windows and Linux.
Pro Designed to be easy to learn
Sequel 3 was made by the folks behind Cubase, and it is meant to be lighter and easier to learn. This program's focus on loops and computer generated drum patterns makes the process easier for people with no music knowledge.
Pro Dedicated beat page
There is a page exclusively meant for generating drum patterns.
Cons
Con Can't fully zoom in and see those eq knobs
Con Proprietary software
This software tramples your freedom.
Con Limited/buggy MIDI support
A problem inherited from Ardour dev base.
Con No GNU/Linux
Does not run on GNU/Linux
Con 32-bit only
While Sequel 3 supports VST3, it oddly (imo) doesn't have a 64-bit installer, meaning you can't load any 64-bit VST3s either. Not sure how it was even possible for that to have ever happened.