When comparing Logitech G602 vs Microsoft Natural 6000, the Slant community recommends Microsoft Natural 6000 for most people. In the question“What is the best mouse for programmers?” Microsoft Natural 6000 is ranked 4th while Logitech G602 is ranked 19th. The most important reason people chose Microsoft Natural 6000 is:
Unlike other, more non-traditional, ergonomic mice, it does not take long to adjust to this one.
Specs
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Pros

Pro Comfortable for palm grip with easy to hit buttons
Great for palm grip along with a the fantastic logitech software for key mapping and profiles.

Pro Great battery life
Good for users that want a wireless mouse without any loss of functionality or need to change the batteries every week

Pro Good optical sensor
Only up to 2500 DPI but it's a great sensor for those that don't need very high DPI.
Pro Can run on single battery for lighter weight
Users can opt to run the device on a single battery to cut down on the weight but this will have an impact on battery life.
Pro Easy to get used to
Unlike other, more non-traditional, ergonomic mice, it does not take long to adjust to this one.
Pro Meant for larger hands
Medium to larger hands will work for this mouse, avoid if you have small hands.
Pro Good tracking
Except for some surfaces, this mouse has good accuracy.
Pro Comfortable and easy to use
Unlike standard mouse designs, this model's buttons, wheel, and palm rest upward to the right. It has the effect of rolling your wrist up off your desk and it feels less stressful on my wrist.
Cons


Con Somewhat heavy
Being that this is a wireless mouse there is the battery weight to contend with. Batteries in the weight of the device is 152 grams, which isn't all that bad considering but still not for users that like a lighter mouse.
The mouse can also be used with a single battery, which is useful for not only reducing weight but also for balancing the mouse. With two batteries the mouse can be a bit slipper on the right side when picking it up as the pinkie and ring fingers don't have as much to grip - but balancing the weight over towards the thumb allows the mice to be more easily picked up as the side buttons allow for a decent place to grip.
Con No wired option
The Logitech G602 does not offer a wired USB option, only wireless.

Con Macro Key Defect
Side buttons are known to register multiple keystrokes occasionally when pressed only once. With bindings such as Ctrl+F4, this naturally has destructive results.

Con Middle mouse button wore out after a year of heavy use
And with no way to open it it's near impossible to fix.
Con Not recharchable
The Natural Wireless 6000 takes two included AA batteries instead of being able to recharge.
Con No left handed version
Con Odd placement of thumb buttons
They are position in a way that requires moving either main finger or thumb.
