When comparing Spybot vs Virus Upload by virus total, the Slant community recommends Spybot for most people. In the question“What are the best free second-opinion malware-scanners for a Windows PC?” Spybot is ranked 2nd while Virus Upload by virus total is ranked 5th. The most important reason people chose Spybot is:
Basic functionality (includes malware removal) can be used for free for non-commercial purposes.
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Pros
Pro Free for personal use
Basic functionality (includes malware removal) can be used for free for non-commercial purposes.
Pro Has a portable version
A portable version of the app can be found here. It allows putting the software on an external storage devices such as an USB thumb stick and running it from there without having to install it on the target machine.
Pro Can be installed in safe mode without issues
Pro Cache database
No need to upload a file if it's been uploaded by someone else, click and see the results instantly.
Pro All in one
Scans single files with multiple virus engines to verify and give second, third, fourth... opinions on the file.
Pro No file type limitations
Can scan any file in any format
Pro Free
Totally free
Cons
Con Bad malware detection
In a test performed by PCMag, Spybot detected just 32% of installed malware.
Con Bad at removing found malware, especially rootkits
In a test performed by PCMag over half of malware that the tool attempted to remove was still running after the attempted cleanup. Rootkit removal often crashes other software.
Con Free version lacks scan scheduling
Premium version of the software is required to schedule scans in advance.
Con Awkward interface elements
Con Size limitation
File size is limited, and the site printed size limits is inaccurate. It appears to be random. Size restrictions range from 5 megabytes to 50 megabytes max, or higher.
Con Slow
Using the desktop upload service is slow. Your upload is queued up and you need to wait. As one of the more popular services of this type, the waits can be from a few seconds to a few minutes.