When comparing Quoll Writer vs Ren'Py, the Slant community recommends Ren'Py for most people. In the question“What are the best tools/sites for self-publishing books?” Ren'Py is ranked 1st while Quoll Writer is ranked 3rd. The most important reason people chose Ren'Py is:
Available on Windows, Linux, OSX, iOS and Android.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Automatic chapter save
Pro Open Source
Pro Frequent updates
Pro Image attachment
Pro Organizing-friendly
Pro Encryption
Any project can be encrypted with a password.
Pro Distraction-free mode
Pro Problem Finder
The Problem Finder helps you to identify issues with your writing.
Pro Import from Microsoft docx
Pro Export projects to docx, epub and html
Pro Achievements
Achievements are aimed at helping you get to know Quoll Writer and providing rewards for writing (after all no one else will be doing it).
Pro Cardboard
Pro Customizable
It's possible to change several aspects from displaying to character's datasheet.
Pro Statistics
Pro Cross-platform
Available on Windows, Linux, OSX, iOS and Android.
Pro Active and friendly community
Pro Reasonably good at creating puzzle and point-and-click games
Cons
Con Windows only
Although it should be possible to make a multi platform version as Quoll is written in Java.
Con No mobile app
Con No cloud support
Unfortunatelly, there's no cloud support, which is very important nowadays.
Con Not for every genre
While technically capable of creating 2D games in any genre, Ren'Py excels in creating visual novels and has a reasonable feature set for creating puzzle and point-and-click games. Other genres are best tackled by other engines.
Con Outdated Documentation and official built-in tutorials
Unfortunately, you will have to hunt relevant info on how Ren'py script works. The Ren'Py dev has the working tutorials on his Patreon, other than that you might as well just code in Python.