When comparing TyranoBuilder vs Ren'Py, the Slant community recommends Ren'Py for most people. In the question“What are the best game engines for point & click adventure games?” Ren'Py is ranked 7th while TyranoBuilder is ranked 11th. The most important reason people chose Ren'Py is:
Available on Windows, Linux, OSX, iOS and Android.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Frequent updates
Pro Flexible
Customize every aspect of your game with the included TyranoScript scripting language
Pro Drag'n'Drop interface
Pro No programming knowledge required
Pro Multi-platform
Create games on Windows or Mac, and export for Windows, iOS, Android, smartphones and tablets, or browsers.
Pro Video backdrops
Pro Dynamic camera functionality
Pro 3D character animation
Pro Cross-platform
Available on Windows, Linux, OSX, iOS and Android.
Pro Active and friendly community
Pro Reasonably good at creating puzzle and point-and-click games
Cons
Con No Linux native application
Con Not for every genre
While technically capable of creating 2D games in any genre, Ren'Py excels in creating visual novels and has a reasonable feature set for creating puzzle and point-and-click games. Other genres are best tackled by other engines.
Con Outdated Documentation and official built-in tutorials
Unfortunately, you will have to hunt relevant info on how Ren'py script works. The Ren'Py dev has the working tutorials on his Patreon, other than that you might as well just code in Python.