When comparing Lutris vs Oracle VirtualBox, the Slant community recommends Lutris for most people. In the question“What are the best tools for running Windows games on Linux?” Lutris is ranked 4th while Oracle VirtualBox is ranked 6th.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro 100% free
Pro Large database of games
Pro Has install scripts for download
Which means very little user interference.
Pro Works with Vagrant
Works with Vagrant, an awesome tool for managing and deploying virtual machine images.
Pro Free, mostly open source and cross-platform
VirtualBox is available for free with source code available here. A "VirtualBox Extension Pack" that includes virtual USB 2.0, VirtualBox RDP & PXE boot support is available only under a commercial license. VirtualBox is available on Windows, Linux, OSX and Solaris.
Pro Can do snapshots
VirtualBox is capable of taking whole-system snapshots and writing them to a backing file.
Cons
Con Requires game's original CD for installation
For the most of the modern games that's easily achievable but for old games (such as Need for Speed 2) this can be a problem since nowadays almost no one keeps their original CDs.
Con Inferior performance
Apart from second-class performance in virtualization, there are some visual glitches with Windows 8.1 on Mavericks.
Con Confusing interface and lacking usability features
VirtualBox might be a bit confusing for beginners - it requires an understanding of a lot more technical details than other VMs.