When comparing wxWidgets vs Sciter, the Slant community recommends wxWidgets for most people. In the question“What are the best cross-platform GUI toolkits?” wxWidgets is ranked 1st while Sciter is ranked 19th. The most important reason people chose wxWidgets is:
wxWidgets was started in 1992 by Julian Smart.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Mature
wxWidgets was started in 1992 by Julian Smart.
Pro Truly native look and feel
It uses the platform's native API rather than emulating the GUI.
Pro Open source
wxWidgets can be used for free or commercial projects, at no cost.
Pro Can do custom control rendering
You can make a custom renderer using the class wxDelegateRendererNative to draw directly any standard control or using the class BackgroundWindow to use any bitmap as a control background.
Pro Forms designers
Several forms designers, like wxFormBuilder, are available.
Pro Designer
A very nice designer: wxCrafter. Free for non-commercial use/evaluation phase (without time expiration). Highly recommended if you plan to use wxWidgets.
Pro Perfect combination: wxFormBuilder + ZeroBrane (wxLua)
Lua Language can provide extra high level scripting
Pro Can use Qt on X11
WxQt is available on X11.
Pro Multi language
Support for C++, C#, Delphi, D, Go, Rust, Powerbuilder. See Go bindings on GitHub. The binding for C# on GitHub, SciterSharp does not seem to be free: in a commercial product you should acquire a commercial license.
Pro Lightweight
Only a single native DLL.
Cons
Con Android port not totally usable yet
See WxAndroid.
Con Uses GTK on X11
WxWidgets uses GTK+ on X11 desktop which well known for looking like an alien on non GTK+ desktops.
Con Has slightly heavy compiled result
Con Written in C++
Con Linux version is not very mature
The Linux version is missing HTML/CSS features when compared to the Windows version.
Con Not fully HTML5 compliant
Lacking HTML5 functionality and W3C standards: grabbing a library like JQuery or Bootstrap and use it in Sciter will not work.
Con Not WYSIWYG
Not WYSIWYG like WebForms or WPF.
